[share_ebook] Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics) - Sandrine Dudoit, Mark J. Van Der Laan


Author: Sandrine Dudoit, Mark J. Van Der Laan

Date: December, 2007

Pages: 624

Publisher: Springer

Category: Software


Posted on 2011-12-20, by 4bookholic.

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Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics)


Multiple Testing Procedures with Applications to Genomics (Springer Series in Statistics)
Sandrine Dudoit, Mark J. Van Der Laan | Springer | December, 2007 | 624 pages | English | PDF

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.


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