Reactive Intermediates: MS Investigations in Solution (repost)

图书介绍

Mass spectrometry could be described, without implying any criticism, as an
example of work in progress. Each time it appears to be approaching maturity,
another breakthrough occurs to expand its usefulness in new areas of science. As
this volume clearly demonstrates, that process is still going on. In the early twentieth
century, mass spectrometry was principally a tool for physicists to study particles
and petroleum chemists to characterize petroleum mixtures.Wider use by chemists
began with the ability to obtain structural information from the spectra of pure
organic molecules. The analytical application of mass spectrometry truly came of age
with its use as a detector for gas chromatography. Indeed, up to the present, advances
in chromatography and mass spectrometry have leapfrogged each other, combining
to create analytical tools that have steadily advanced in selectivity and detection limit
for over two decades. The power of these tools is such that they have found critical
applications in virtually every area of science, engineering, and medicine.
From the standpoint of mass spectrometric instrumentation, the story of this
evolution has taken place on four fronts:

(1) Methods of separating ions of different atomic or molecular masses
(2) Methods of obtaining more chemical information by tandem mass spectrometry
(3) Methods of ionizing analyte molecules